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KMID : 1161420110140121583
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Journal of Medicinal Food
2011 Volume.14 No. 12 p.1583 ~ p.1589
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Oral Administration of an Enzymatic Protein Hydrolysate from the Green Microalga Chlorella vulgaris Enhances the Nutritional Recovery of Malnourished Mice
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Morris Humberto J.
Carrillo Olimpia V.
Alonso Maria E.
Bermudez Rosa C.
Almarales Angel
Llaurado Gabriel
Lebeque Yamila
Fontaine Roberto
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Abstract
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This study examined the effects of oral administration of an enzymatic protein hydrolysate from green microalga Chlorella vulgaris (Cv-PH) on the nutritional recovery of malnourished Balb/c mice after a 3-day fasting period. Mice were refed with commercial diet supplemented or not supplemented with Cv-PH (500?mg/kg) for 8 days. Regardless of the diet used during refeeding, animal body weights and serum protein concentrations did not differ between groups. Mice given Cv-PH had a significant increase in hemoglobin concentrations. Most serum amino acid levels were similar in the control and Cv-PH animals. Starved mice refed with Cv-PH showed normal liver functions, as judged by liver weight, protein concentration, and the enzymatic activities of cholinesterase and arginase. Cv-PH increased DNA, protein content, and gut-mucosal weight. In addition, brush-border oligosaccharidase activities were also higher in the Cv-PH group. These findings suggest that Chlorella protein hydrolysate can be used to develop specific formulations suitable for pharmacologic nutrition.
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KEYWORD
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Chlorella, mice, nutrition, protein hydrolysate
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